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Vol 6, No 2 (2018)

Inflation of the scientific balloon in Antarctica carrying the Cosmic Ray Exposure Sequencing Science payload on the BACCUS hardware. Photo by Scott Miller of the Columbia Scientific Balloon Facility, NASA. Article on page 54 of this issue.
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Vol 6, No 1 (2018)

Montage of swimming Danio rerio (zebrafish) larvae. See article on page 37 of this issue. Photo by Pedro Llanos.


Cover Page

Vol 5, No 2 (2017)

Liftoff of Blue Origin’s new suborbital New Shepard vehicle. From: "Analysis of Vibratory Data Collected by the Space Acceleration Measurement System (SAMS) on Blue Origin, June 19, 2016.” K. McPherson et al., p. 2
Cover Page

Vol 5, No 1 (2017)

Spaceflight and the Antibody Repertoire. This issue features a paper detailing the bioinformatic workflow developed for assessing the effects of spaceflight on the antibody repertoire (p 2). Top right: Animal Enclosure Module (AEM) hardware was validated on the Rodent Research-1 (RR1) mission. High throughput sequencing (HTS) data sets of RR1 animals were made available by NASA GeneLab and spleen tissues were made available by NASA Ames. These were mined for antibody repertoire assessment. Bottom right: Antibodies are heterodimers of heavy (IgH) and light immunoglobulin chains that are encoded on separate loci. A diagram of the IgH locus is pictured. Multiple copies of Variable- (V), Diversity- (D), and Joining- (J) gene segments exist within the germline IgH locus. Somatic recombination at the IgH locus during early B-cell development yields immunoglobulin sequences with one V-D-J-gene segment combination, collectively resulting in a repertoire of antibody specificities that can bind to antigens for host defense. Background image: The antibody repertoire can be characterized by assessing gene segment usage in HTS data sets. Image credits: AEM: NASA, picture of C57BL/6 Mouse: Chapes laboratory (not to scale).


Cover Page

Vol 4, No 2 (2016)

Taking plants to space. This issue features several papers describing preparations and calibrations necessary for developing plant spaceflight payloads, and images from this theme are included in the cover collage. Top left: Fitzgerald (p 8), the optimization of Light rail system using far-red LEDs to impose dormancy on Arabidopsis seeds to aid in their transport to the ISS, along with a scanning electron micrograph of a dormant Arabidopsis seed. Top right: Vandenbrink (p 38), an image of terrestrially-grown Arabidopsis seedlings in an EMCS cassette overlaid with an image of seedlings grown in the EMCS hardware on the ISS. Bottom right: LeFrois (p 28), three different genotypes of Arabidopsis slated for an upcoming flight experiment overlaid with the graphical representations of DNA methylation levels in a gene of interest. Middle left: Hutchinson (p 20), a stack of 60 mm nutrient agar Petri plates that have been densely plated with Arabidopsis seeds for use in the BRIC spaceflight hardware, along with a plate showing germinated Arabidopsis seeds after growing four days in the dark.
Cover Page

Vol 4, No 1 (2016)

Differentiated human blood derived endothelial cells expressing von Willebrand factor, a characteristic endothelial cell marker. Cells cultured under simulated microgravity using microcarrier beads and a rotating wall vessel bioreactor. The effect of simulated microgravity was studied to better understand vascular health following spaceflight. From: “Altered Functions of Human Blood-Derived Vascular Endothelial Cells by Simulated Microgravity.” Ramaswamy et al., p 2.


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Vol 3, No 2 (2015)

A hypothetical model showing that a gradient of extracellular nucleotides could activate calcium channels, contributing to a calcium differential that is essential for gravity-directed polarization in Ceratopteris richardii spores. From: “New Insights in Plant Biology Gained from Research in Space.” Cannon et al., p 3.
Cover Page

Vol 3, No 1 (2015)

“Secretory proteins of salivary glands, whose expression is regulated by cyclic AMP-PKA
signaling, respond to microgravity. A component of the signaling pathway, RII, may serve as a stress
biomarker.” M.I. Mednieks et al., p. 2


Cover Page

Vol 2, No 2 (2014)

"Exposing Microorganisms in the Stratosphere (E-MIST), a NASA balloon payload microbiology experiments, designed for stratospheric microbiology experiments, is shown 37.6 km above sea level during its first test flight on 24 August 2014." Smith et al, p. 70.
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Vol 2, No 1 (2014)

"The eye is subjected to the combination of microgravity and high energy particle radiation
during spaceflight. A study that examines the histology and gene expression changes in the retina of mice exposed to spaceflight compared to ground controls suggest that these effects may have implications in retinal health." Theriot
and Zanello, p. 3.


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Vol 1, No 1 (2013)

“Housing in the Animal Enclosure Module Spaceflight Hardware Increases Trabecular Bone Massin Ground-Control Mice.” S.A. Lloyd et al., p. 2.


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Vol 26, No 2 (2012)

VESGEN analysis of vascular network from normal mouse colon to quantify inflammatory progression. From: “For Application to Human Spaceflight and ISS Experiments: VESGEN Mapping of Microvascular Network Remodeling during Intestinal Inflammation.” P. Parsons-Wingerter and H.-C. Reinecker, p. 2.
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Vol 26, No 1 (2012)

Radishes grown at various pressures and oxygen partial pressure. From: “Radish (Raphanus sativa L. cv. Cherry Bomb II) Growth, Net Carbon Exchange Rate, and Transpiration at Decreased Atmospheric Pressure and/or Oxygen.” C.A. Wehkamp, et al., p. 3


Cover Page

Vol 25, No 1 (2011)

Hatchling Bobtail squid Euprymna scolopes used as a model organism to assess the role of
microgravity in symbiosis-induced animal development. From: “Potential of the Euprymna/Vibrio symbiosis as a model to assess the impact of microgravity on bacteria-induced animal development.” J. Foster, et al., p. 45.

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ISSN: 2332-7774